Creatinine is related to human kidney function, and a mild creatinine increase does not affect fertility. However, if creatinine is significantly increased, it indicates that kidney function has been seriously damaged at this time, and it generally has a certain impact on fertility.
Creatinine includes two major categories, that is, blood creatinine, urine creatinine, the general people often say that affects kidney function is blood creatinine. However, when it comes to truly assessing the kidney function of patients, blood creatinine cannot be looked at alone, but blood creatinine and urine creatinine should be combined for analysis.
Blood creatinine is also called endogenous blood creatinine in medicine, which is the product of human muscle metabolism. In muscle, creatine is slowly formed into creatinine through irreversible dehydration reaction, and then released into the blood and excreted in urine, so blood creatinine and the total amount of muscle in the body is closely related. In blood creatinine, there are differences according to gender, male blood creatinine is generally 53-140μmol/L, and female blood creatinine is 53-106μmol/L.
Urine creatinine is derived from blood creatinine, which is produced by muscle metabolism in the human body, and blood creatinine is filtered through the glomerulus and eventually excreted in the form of urine. Urinary creatinine is often used to evaluate urinary albumin excretion in clinic. By checking the ratio of urinary albumin to urinary creatinine, the excretion of urinary microalbumin is observed to determine whether there is early renal function impairment. The normal value of urinary creatinine in the average person is 8.4-13.25mmol/L.
Urine creatinine will decrease and blood creatinine will increase. Because renal failure decreases at the glomerular filtration rate, blood creatinine filtration from the glomerular decreases, resulting in less creatinine in the urine and more creatinine in the blood. Therefore, if a patient has kidney failure, it is necessary to look at the two indicators of blood creatinine and urine creatinine.
The body's kidney compensatory ability is very strong, when the kidney is mildly damaged, the average person has no obvious discomfort, so the creatinine check at this time may not necessarily reflect the kidney damage. However, when the patient presents with severe uremic symptoms, such as anemia, nausea, vomiting, and gastrointestinal symptoms, creatinine has been significantly elevated. Therefore, when measuring creatinine, it can not reflect early kidney disease, but the appearance of creatinine certainly indicates kidney damage.
For most patients with kidney disease, creatinine levels generally do not rise until kidney failure has progressed to moderate levels. Therefore, as long as the creatinine of kidney disease patients exceeds the standard a little, the harm is great, and it is necessary to actively treat the primary disease and control complications.
