The European Union has approved a new indication for Jardiance (Englaglizin) for the treatment of adults with chronic kidney disease, which is expected to improve the management of treatment for more than 47 million patients with chronic kidney disease in the EU. In the EU sugar friends circle, kidney friends circle caused a small wave of sensation. (Note: as far as the current domestic, severe kidney damage, end-stage kidney disease or dialysis contraindicated)
Previously, Jardiance (Enaglizin) has been approved in China for adult type 2 diabetes, adult heart failure with reduced ejection fraction, adult heart failure with preserved ejection fraction and other indications, which has greatly helped to slow down the development of kidney disease in CKD patients in China.
Chronic kidney disease (CKD) is a serious and common progressive disease that affects approximately 850 million people worldwide and approximately 180 million people in China. It is caused by primary kidney disease and a variety of secondary kidney diseases and a variety of congenital, hereditary kidney diseases and other clinical collectively referred to kidney disease. Its treatment cycle is long, once it is confirmed that there is no possibility of cure, long-term medication or dialysis treatment is needed, the main purpose of treatment is to delay the failure of renal function, and enter the uremia stage as late as possible.
Primary glomerulonephritis is the most common cause of chronic kidney disease in China, followed by diabetes, hypertension, lupus nephritis, obstructive nephropathy and polycystic kidney disease. Some acute kidney injury can also lead to chronic kidney disease. Chronic kidney disease can also be induced if long-term use of drugs that may damage the kidneys, such as non-steroidal anti-inflammatory drugs such as ibuprofen.
According to the rate of decline of glomerular filtration rate, it can be divided into:
Stage 1 Chronic kidney disease: Normal renal function, glomerular filtration rate ≥90ml/min·1.73m2, and kidney damage.
Stage 2 Chronic kidney disease: mild decline in renal function, glomerular filtration rate of 60 ~ 89ml/min·1.73m2, kidney damage.
Stage 3 Chronic kidney disease: moderate renal function decline, glomerular filtration rate of 30 ~ 59ml/min·1.73m2.
Stage 4 Chronic kidney disease: severe renal function decline, glomerular filtration rate of 15 ~ 29ml/min·1.73m2.
Stage 5 Chronic kidney disease: Renal failure, glomerular filtration rate < 15ml/min·1.73m2.
Early prevention, early detection, early treatment, and regular urine testing are helpful for early detection and diagnosis of kidney disease.
